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Clinic 45
Clinic 45

Clinic 45

Med spa · 3 locations

Clinic 45 is an independent practice owned and supervised by Joseph E. Sleiman MD, and it describes itself as a medical spa and medical weight loss and wellness clinic. The main location is at 8221 Gulf Fwy, Suite 400, in Houston. Two sister clinics, Texas Weight Loss - Southwest and Texas Weight Loss - Kirby, are on Southwest Freeway. The main clinic is open Monday to Friday 7:00 am to 5:00 pm and Saturday 8:30 am to 2:00 pm. Southwest is closed Mondays, open Tuesday 6:00 am to 3:00 pm, open Wednesday to Friday 8:00 am to 5:00 pm, and open Saturday 8:30 am to 2:00 pm. Kirby is closed Mondays, open Tuesday to Friday 8:00 am to 5:00 pm, and open Saturday 8:30 am to 2:00 pm. The clinic says it serves clients across Houston and surrounding areas, and main phone and email details are published on the site.

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About

Clinic 45 is an independent practice owned and supervised by Joseph E. Sleiman MD, and it describes itself as a medical spa and medical weight loss and wellness clinic. The main location is at 8221 Gulf Fwy, Suite 400, in Houston. Two sister clinics, Texas Weight Loss - Southwest and Texas Weight Loss - Kirby, are on Southwest Freeway. The main clinic is open Monday to Friday 7:00 am to 5:00 pm and Saturday 8:30 am to 2:00 pm. Southwest is closed Mondays, open Tuesday 6:00 am to 3:00 pm, open Wednesday to Friday 8:00 am to 5:00 pm, and open Saturday 8:30 am to 2:00 pm. Kirby is closed Mondays, open Tuesday to Friday 8:00 am to 5:00 pm, and open Saturday 8:30 am to 2:00 pm. The clinic says it serves clients across Houston and surrounding areas, and main phone and email details are published on the site.

The weight loss program builds an individualized plan with monthly follow-up visits from licensed medical providers. The first visit is in person and includes blood tests for liver, kidney and thyroid function, a medical consultation, a body composition analysis and a vitamin B-12 injection, listed at $150 for a new weight loss visit and $110 for a follow-up. An EKG may be required in some cases for patient safety. Prescription medication such as phentermine pills or semaglutide injections may be considered when medically indicated; eligibility is decided at the visit, and medication is an additional charge. Semaglutide is listed at $100 to $275 depending on dosage, and tirzepatide injections are also offered. Patients can also get personalized diet plans in conjunction with Texas Weight Loss, consultations about bariatric surgery, and telemedicine visits by secure video or phone once an initial in-person visit with lab work and an InBody scan is complete. The site says some medical services may be eligible for insurance coverage.

The aesthetic menu includes Botox Cosmetic, Xeomin, Dysport and Jeuveau, along with several Juvederm XC fillers used for different areas of the face. Other treatments include Kybella, laser hair removal, RF microneedling, skin tightening, Venus Legacy, PRP facelift, FemiLift and FemiTight, PRP hair restoration, and Smartlipo Triplex, which the site describes as a less-invasive surgery. All Cosmetic Consults are listed at $60. The site says Botox Cosmetic results may begin to show within 24 to 48 hours, with full results after 30 days lasting up to four months, and that the effects are not permanent. The clinic publishes before and after photos of client results and describes its aesthetic tools and techniques as industry-leading.

Internal medicine services include IV hydration, which can include B-12 and vitamins, and a FibroScan liver assessment described as a noninvasive test that takes about 10 minutes. Myers' Cocktail infusions are listed at $130, with the Immunity version at $160 and the Performance version at $200. Several named IV drips are each listed at $275. The site also lists testosterone replacement therapy and lipotropic injections, and says past clients have used BOTOX, KYBELLA, Semaglutide and Tirzepatide injections for fat removal from the back, neck, flanks and abdomen.

The weight loss program is low-carbohydrate and high-fat, with a ketogenic option when appropriate, and the clinic treats ketogenic eating as a long-term lifestyle change rather than a short diet. The program rests on five components: nutritional quality, sustainability, effectiveness, health benefits and supporting research.

Locations

Specials & promotions

  • 20% off for weight loss patients

    Offered exclusively to weight loss patients

    On their website as of Oct 28, 2026 · Where we saw it

Services

Final prices may vary.

Individualized medical weight loss plans with monthly follow-ups, including Semaglutide and tirzepatide options, lipotropic injections, personalized diet plans and telemedicine check-ups.

  • Single Energy Boosting Shot $20
  • Body Composition Analysis $25
  • Single Fat Burner Shot $25
  • Package of 4 Energy Boosting Shots $60
  • Package of 4 Fat Burner Shots $80
  • Semaglutide monthly supply $100
  • Follow-up $110
  • Weight Loss Follow-up $110
  • New Weight Loss Visit $150

Treatments such as laser hair removal, RF microneedling, skin tightening, Kybella, Venus Legacy, PRP facelift, FemiLift, FemiTight and PRP hair restoration, plus cosmetic consults.

  • All Cosmetic Consults $60
  • Botox & Dermal Fillers Price at booking
  • Kybella Price at booking
  • Laser Hair Removal Price at booking
  • Microneedling Price at booking
  • PRP Facelift Price at booking
  • Skin Tightening Price at booking
  • Venus Price at booking
  • Facelift Price at booking
  • PRP Price at booking

Neuromodulator options from four named toxins and several Juvederm XC fillers, each suited to different areas of the face.

  • Botox® Price at booking
  • Dysport® Price at booking
  • Jeuveau® Price at booking
  • Xeomin® Price at booking
  • JUVÉDERM® Ultra Plus XC Price at booking
  • JUVÉDERM® Ultra XC Price at booking
  • Juvéderm® Volbella® Xc Price at booking
  • Juvéderm® Vollure® Xc Price at booking
  • Juvéderm® Voluma® Xc Price at booking

IV hydration, Myers' Cocktail infusions, named IV drips, a FibroScan liver assessment and testosterone replacement therapy.

  • Myers' Cocktail $130
  • Myers' Cocktail + Immunity $160
  • Myers' Cocktail + Performance $200
  • Beauty $275
  • Beauty Drip $275
  • Detox Drip $275
  • Immunity Drip $275
  • Performance $275
  • Performance Drip $275
  • Skinny Drip $275
  • Fibro Scan Price at booking
  • IV Hydration Price at booking
  • Semaglutide $100–$275

Photos

  • Lip filler before and after results on a client
  • Lip filler before and after close-up results
  • Lip filler multi-angle before and after results
  • Lip filler side-angle before and after results
  • Lip filler before and after on a client's lips
  • Chin and lip filler side-profile before and after
  • Lip and chin filler side-profile before and after
  • Jawline and lip filler side-profile before and after
  • Lip filler before and after on a client
  • Multi-angle dermal filler before and after collage with clinic watermark
  • before and after lip filler results collage
  • before and after lip filler results collage
Highlights
  • Individualized medical weight loss plans with monthly follow-ups from licensed providers
  • Semaglutide and tirzepatide options, with lab work and body composition analysis at the first visit
  • Telemedicine follow-ups after an initial in-person visit
  • Aesthetic menu covering four named toxins and several Juvederm XC fillers
  • Three Houston locations, including two sister clinics under Texas Weight Loss
  • Published before and after photos of client results
Good for
  • Medical weight loss
  • Ongoing monthly weight loss follow-up
  • Telehealth check-ups after a first in-person visit
  • Injectable treatments
  • IV therapy
  • Saturday appointments
Treats
  • Weight loss
  • Blood sugar control alongside diet and exercise
  • Fat in the back, neck, flanks or abdomen
  • Lines and wrinkles
  • Lip and perioral lines
  • Under-eye hollows
  • Unwanted hair
  • Skin laxity
  • Hair restoration
Techniques
  • Semaglutide injections
  • Tirzepatide injections
  • Lipotropic injections
  • Vitamin B-12 injections
  • Kybella injections
  • RF microneedling
  • Laser hair removal
  • Skin tightening
  • Venus Legacy
  • PRP facelift

Products & treatments

  • Botox Cosmetic
  • Dysport
  • Jeuveau
  • Xeomin
  • Juvederm Voluma XC
  • Juvederm Vollure XC
  • Juvederm Ultra Plus XC
  • Juvederm Ultra XC
  • Juvederm Volbella XC
  • Phentermine appetite suppressant pills
  • B-complex, glutathione, NAD+ and amino acid injections
  • Immunity, Performance, Detox, Beauty, Skinny and Beauty Drip IV blends

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